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El descubrimiento de las celulas madres en los dientes primarios de los niños y en los molares tendran un fuerte impacto en la medicina del siglo 21, y pondrá a la Odontología en la vanguardia de la tecnologia en la medicina. La Dra. Pamela Gehton robey, Ph.D, Chief Craniofacial and Skeletal Disease Branch, National Institute of Dental and Craniofacial Research of the National Institute of Health, Department of Health and Human Services, vió de antemano el valor de preservar las celulas dentales y alentó a promover esta práctica. Usted puede leer un resumen de su discurso en el 2005 en la Asociacion Dental Americana en http://www.ada.org/public/media/releases/0506_release04.asp Como este descubrimiento es tan reciente, y las celulas de los dientes primarios y molares son obtenidas tan facilmente, es seguro que una gran cantidad de investigaciones seran conducidas ustilizando estas células - Investigaciones que conducirán a nuevas curas para una serie de enfermedades y transtornos, incluyendo transtornos neuronales degenerativos tales como Mal de Alzheimer y Parkinson, ALS o Lou Gehrig; condiciones crónicas del corazón tales como insuficiencia cardíaca congestiva y cardiopatía isquémica crónica. Estas células tambien pueden ser utilizadas para tratar enfermedades periodontales, el crecimiento de los huesos y los dientes de reemplazo. Una de las más importantes aplicaciones potenciales de este material se utiliza para el tratamiento de la parálisis debido a la lesión de la médula espinal - el tratamiento que ya se ha hecho uso de las células madre mesenquimales de otras fuentes. Terapia de células madre no sólo tratar los síntomas, la terapia de células madre cura enfermedades. El futuro de las terapias con células madre es prometedora. La aplicación de la terapia de células madre está siendo llevada a cabo por muchas de las más brillantes mentes en las mejores instituciones todo el mundo. Actual de financiación para la investigación con células madre es en exceso de $ 8 mil millones en todo el mundo, y hay miles de ensayos clínicos en curso que involucran a las células madre. Los enlaces que figuran abajo son una muestra de la investigación en curso utilizando los mismos tipos de células encontradas en los dientes primarios de los niños y molares :
Publicaciones Científicas Relevantes :
Publications are in reverse chronological order 2008 Publications Isolation of Distinct Progenitor Stem Cell Populations from Dental Pulp. Waddington RJ, Youde SJ, Lee CP, Sloan AJ. Cells Tissues Organs. 2008 Aug 14. PMID: 18701814 http://www.ncbi.nlm.nih.gov/pubmed/18701814?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Putative Dental Pulp Derived Stem/Stromal Cells Promote Proliferation and Differentiation of Endogenous Neural Cells in the Hippocampus of Mice. Huang AH, Snyder BR, Cheng PH, Chan AW. Stem Cells. 2008 Aug 7 http://www.ncbi.nlm.nih.gov/sites/entrez Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. Cordeiro MM, Dong Z, Kaneko T, Zhang Z, Miyazawa M, Shi S, Smith AJ, Nör JE. J Endod. 2008 Aug;34(8):962-9. PMID: 18634928 http://www.ncbi.nlm.nih.gov/pubmed/18634928?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Arthur A, Rychkov G, Shi S, Koblar SA, Gronthos S. Stem Cells. 2008 Jul;26(7):1787-95. http://www.ncbi.nlm.nih.gov/pubmed/18499892?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Self-Assembling Peptide Amphiphile Nanofibers as a Scaffold for Dental Stem Cells. Galler KM, Cavender A, Yuwono V, Dong H, Shi S, Schmalz G, Hartgerink JD, D'Souza RN. Tissue Eng Part A. 2008 Jul 17. PMID: 18636949 http://www.ncbi.nlm.nih.gov/pubmed/18636949?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Stem cells and periodontal regeneration. Lin NH, Gronthos S, Bartold PM. Aust Dent J. 2008 Jun;53(2):108-21. http://www.ncbi.nlm.nih.gov/pubmed/18494965?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Collection, cryopreservation, and characterization of human dental pulp-derived mesenchymal stem cells for banking and clinical use. Perry BC, Zhou D, Wu X, Yang FC, Byers MA, Chu TM, Hockema JJ, Woods EJ, Goebel WS. Tissue Eng Part C Methods. 2008 Jun;14(2):149-56. PMID: 18489245 http://www.ncbi.nlm.nih.gov/pubmed/18489245?ordinalpos=22&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction. Gandia C, Armiñan A, García-Verdugo JM, Lledó E, Ruiz A, Miñana MD, Sanchez-Torrijos J, Payá R, Mirabet V, Carbonell-Uberos F, Llop M, Montero JA, Sepúlveda P. Stem Cells. 2008 Mar;26(3):638-45. Epub 2007 Dec 13. http://www.ncbi.nlm.nih.gov/pubmed/18079433?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Human dental pulp stem cells differentiate into neural crest- derived melanocytes and have label-retaining and sphere-forming abilities. Stevens A, Zuliani T, Olejnik C, Leroy H, Obriot H, Kerr-Conte J, Formstecher P, Bailliez Y, Polakowska RR. Stem Cells Dev. 2008 Mar 25. PMID: 18393638 http://www.ncbi.nlm.nih.gov/pubmed/18393638?ordinalpos=28&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum In vivo evaluation of human dental pulp stem cells differentiated towards multiple lineages. Zhang W, Walboomers XF, Van Kuppevelt TH, Daamen WF, Van Damme PA, Bian Z, Jansen JA. J Tissue Eng Regen Med. 2008 Mar-Apr;2(2-3):117-25. PMID: 18338838 http://www.ncbi.nlm.nih.gov/pubmed/18338838?ordinalpos=31&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Reconstruction of large cranial defects in nonimmunosuppressed experimental design with human dental pulp stem cells. de Mendonça Costa A, Bueno DF, Martins MT, Kerkis I, Kerkis A, Fanganiello RD, Cerruti H, Alonso N, Passos-Bueno MR. J Craniofac Surg. 2008 Jan;19(1):204-10. PMID: 18216690 http://www.ncbi.nlm.nih.gov/pubmed/18216690?ordinalpos=45&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Dental pulp stem cells: a promising tool for bone regeneration. d'Aquino R, Papaccio G, Laino G, Graziano A. Stem Cell Rev. 2008 Spring;4(1):21-6. PMID: 18300003 http://www.ncbi.nlm.nih.gov/pubmed/18300003?ordinalpos=36&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum 2007 Publications Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into immunocompromised mice. Otaki S, Ueshima S, Shiraishi K, Sugiyama K, Hamada S, Yorimoto M, Matsuo O. Cell Biol Int. 2007 Oct;31(10):1191-7. Epub 2007 Apr 14. PMID: 17524678 [PubMed - in process] http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17524678&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Human postnatal dental pulp cells co-differentiate into osteoblasts and endotheliocytes: a pivotal synergy leading to adult bone tissue formation. d'Aquino R, Graziano A, Sampaolesi M, Laino G, Pirozzi G, De Rosa A, Papaccio G. Cell Death Differ. 2007 Jun;14(6):1162-71. Epub 2007 Mar 9. PMID: 17347663 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17347663&ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Concave pit-containing scaffold surfaces improve stem cell-derived osteoblast performance and lead to significant bone tissue formation. Graziano A, d'Aquino R, Cusella-De Angelis MG, Laino G, Piattelli A, Pacifici M, De Rosa A, Papaccio G. PLoS ONE. 2007 Jun 6;2:e496. PMID: 17551577 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17551577&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Transplantation of mesenchymal stem cells is an optimal approach for plastic surgery. Fang D, Seo BM, Liu Y, Sonoyama W, Yamaza T, Zhang C, Wang S, Shi S. Stem Cells. 2007 Apr;25(4):1021-8. Epub 2006 Dec 14. PMID: 17170063 http://www.ncbi.nlm.nih.gov/pubmed/17170063?ordinalpos=30&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum In vitro stem cell cultures from human dental pulp and periodontal ligament: new prospects in dentistry. Ballini A, De Frenza G, Cantore S, Papa F, Grano M, Mastrangelo F, Tete S, Grassi FR. Int J Immunopathol Pharmacol. 2007 Jan-Mar;20(1):9-16. Review. PMID: 17346423 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17346423&ordinalpos=20&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Multilineage potential of STRO-1+ rat dental pulp cells in vitro. Yang X, Zhang W, van den Dolder J, Walboomers XF, Bian Z, Fan M, Jansen JA. J Tissue Eng Regen Med. 2007 Mar-Apr;1(2):128-35. PMID: 18038401 http://www.ncbi.nlm.nih.gov/pubmed/18038401?ordinalpos=52&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Human dental pulp stem cells--isolation and long term cultivation. Suchánek J, Soukup T, Ivancaková R, Karbanová J, Hubková V, Pytlík R, Kucerová L. Acta Medica (Hradec Kralove). 2007;50(3):195-201. PMID: 18254273 http://www.ncbi.nlm.nih.gov/pubmed/18254273?ordinalpos=42&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum 2006 Publications Mesenchymal stem cell-mediated functional tooth regeneration in Swine. Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, Zhang C, Liu H, Gronthos S, Wang CY, Shi S, Wang S. PLoS ONE. 2006 Dec 20;1:e79. PMID: 17183711 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17183711&query_hl=1&itool=pubmed_docsum Transplantation of Mesenchymal Stem Cells is an Optimal Approach for Plastic Surgery. Fang D, Seo BM, Liu Y, Sonoyama W, Yamaza T, Zhang C, Wang S, Shi S. Stem Cells. 2006 Dec 14; PMID: 17170063 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17170063&query_hl=1&itool=pubmed_docsum The performance of human dental pulp stem cells on different three-dimensional scaffold materials. Zhang W, Frank Walboomers X, van Kuppevelt TH, Daamen WF, Bian Z, Jansen JA. Biomaterials. 2006 Nov;27(33):5658-68. Epub 2006 Aug 17. PMID: 16916542 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16916542&ordinalpos=37&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Differentiation of dental pulp stem cells into regular-shaped dentin-pulp complex induced by tooth germ cell conditioned medium. Yu J, Deng Z, Shi J, Zhai H, Nie X, Zhuang H, Li Y, Jin Y. Tissue Eng. 2006 Nov;12(11):3097-105. PMID: 17518625 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17518625&ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Craniofacial tissue engineering by stem cells. Mao JJ, Giannobile WV, Helms JA, Hollister SJ, Krebsbach PH, Longaker MT, Shi S. J Dent Res. 2006 Nov;85(11):966-79. Review. PMID: 17062735 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17062735&ordinalpos=29&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Multilineage differentiation potential of stem cells derived from human dental pulp after cryopreservation. Zhang W, Walboomers XF, Shi S, Fan M, Jansen JA. Tissue Eng. 2006 Oct;12(10):2813-23. PMID: 17518650 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17518650&ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Long-term cryopreservation of dental pulp stem cells (SBP-DPSCs) and their differentiated osteoblasts: a cell source for tissue repair. Papaccio G, Graziano A, d'Aquino R, Graziano MF, Pirozzi G, Menditti D, De Rosa A, Carinci F, Laino G. J Cell Physiol. 2006 Aug;208(2):319-25. PMID: 16622855 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16622855&ordinalpos=49&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Cluster analysis and gene expression profiles: a cDNA microarray system-based comparison between human dental pulp stem cells (hDPSCs) and human mesenchymal stem cells (hMSCs) for tissue engineering cell therapy. Yamada Y, Fujimoto A, Ito A, Yoshimi R, Ueda M. Biomaterials. 2006 Jul;27(20):3766-81. Epub 2006 Mar 24. PMID: 16563496 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16563496&ordinalpos=50&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum In vitro bone production using stem cells derived from human dental pulp. Laino G, Carinci F, Graziano A, d'Aquino R, Lanza V, De Rosa A, Gombos F, Caruso F, Guida L, Rullo R, Menditti D, Papaccio G. J Craniofac Surg. 2006 May;17(3):511-5. PMID: 16770190 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16770190&ordinalpos=46&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum An approachable human adult stem cell source for hard-tissue engineering. J Cell Physiol. 2006 Mar;206(3):693-701. Laino G, Graziano A, d'Aquino R, Pirozzi G, Lanza V, Valiante S, De Rosa A, Naro F, Vivarelli E, Papaccio G. PMID: 16222704 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16222704&query_hl=6&itool=pubmed_docsum Dental pulp stem cells. Liu H, Gronthos S, Shi S. Methods Enzymol. 2006;419:99-113. PMID: 17141053 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17141053&ordinalpos=26&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum 2005 Publications A new population of human adult dental pulp stem cells: a useful source of living autologous fibrous bone tissue (LAB). Laino G, d'Aquino R, Graziano A, Lanza V, Carinci F, Naro F, Pirozzi G, Papaccio G.
J Bone Miner Res. 2005 Aug;20(8):1394-402. Epub 2005 Mar 28.
PMID: 16007337 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16007337&query_hl=29 The efficacy of mesenchymal stem cells to regenerate and repair dental structures. Shi S, Bartold PM, Miura M, Seo BM, Robey PG, Gronthos S.
Orthod Craniofac Res. 2005 Aug;8(3):191-9.
PMID: 16022721 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16022721&query_hl=4 Making a tooth: growth factors, transcription factors, and stem cells. Zhang YD, Chen Z, Song YQ, Liu C, Chen YP.
Cell Res. 2005 May;15(5):301-16.
PMID: 15916718 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15916718&query_hl=12 Identification and isolation of human dental pulp stem cells.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2005 May;40(3):244-7. Chinese.
PMID: 15938892 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15938892&query_hl=33 Differentiation ability of rat postnatal dental pulp cells in vitro. Zhang W, Walboomers XF, Wolke JG, Bian Z, Fan MW, Jansen JA.
Tissue Eng. 2005 Mar-Apr;11(3-4):357-68.
PMID: 15869416 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15869416&query_hl=36 Isolation and identification of huamn dental pulp stem cells.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2005 Feb;23(1):75-8. Chinese.
PMID: 15804030 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15804030&query_hl=33 2004 Publications Reconstruction of human mandible by tissue engineering. Gronthos S.
Lancet. 2004 Aug 28-Sep 3;364(9436):735-6. No abstract available.
PMID: 15337383 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15337402 Investigation of multipotent postnatal stem cells from human periodontal ligament. Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY, Shi S.
Lancet. 2004 Jul 10-16;364(9429):149-55.
PMID: 15246727 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15246727&query_hl=10 Dentonin, a fragment of MEPE, enhanced dental pulp stem cell proliferation. Liu H, Li W, Gao C, Kumagai Y, Blacher RW, DenBesten PK.
J Dent Res. 2004 Jun;83(6):496-9.
PMID: 15153459 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15153459&query_hl=26 Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro; implications for tissue engineering and repair in the nervous system. Nosrat IV, Smith CA, Mullally P, Olson L, Nosrat CA.
Eur J Neurosci. 2004 May;19(9):2388-98.
PMID: 15128393 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15128393&query_hl=6 2003 Publications Comparison of stem-cell-mediated osteogenesis and dentinogenesis.
J Dent Res. 2003 Dec;82(12):976-81. Batouli S, Miura M, Brahim J, Tsutsui TW, Fisher LW, Gronthos S, Robey PG, Shi S.
PMID: 14630898 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14630898&query_hl=10 Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp.
Shi S, Gronthos S. J Bone Miner Res. 2003 Apr;18(4):696-704.
PMID: 12674330 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12674330&query_hl=1 SHED: stem cells from human exfoliated deciduous teeth. Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S.
Proc Natl Acad Sci U S A. 2003 May 13;100(10):5807-12. Epub 2003 Apr 25.
PMID: 12716973 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12716973&query_hl=4 Responses of rat trigeminal neurones to dental pulp cells or fibroblasts overexpressing neurotrophic factors in vitro. Lillesaar C, Arenas E, Hildebrand C, Fried K.
Neuroscience. 2003;119(2):443-51.
PMID: 12770558 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12770558&query_hl=6 Analysis of tooth formation by reaggregated dental mesenchyme from mouse embryo. Yamamoto H, Kim EJ, Cho SW, Jung HS.
J Electron Microsc (Tokyo). 2003;52(6):559-66.
PMID: 14756244 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14756244&query_hl=6 Publications before 2003 Tissue engineering of complex tooth structures on biodegradable polymer scaffolds. Young CS, Terada S, Vacanti JP, Honda M, Bartlett JD, Yelick PC.
J Dent Res. 2002 Oct;81(10):695-700.
PMID: 12351668 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12351668&query_hl=4 Stem cell properties of human dental pulp stem cells. Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, DenBesten P, Robey PG, Shi S.
J Dent Res. 2002 Aug;81(8):531-5.
PMID: 12147742 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12147742&query_hl=2 Comparison of human dental pulp and bone marrow stromal stem cells by cDNA microarray analysis. Shi S, Robey PG, Gronthos S.
Bone. 2001 Dec;29(6):532-9.
PMID: 11728923 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11728923&query_hl=10 Dental pulp cells produce neurotrophic factors, interact with trigeminal neurons in vitro, and rescue motoneurons after spinal cord injury.
Nosrat IV, Widenfalk J, Olson L, Nosrat CA. Dev Biol. 2001 Oct 1;238(1):120-32.
PMID: 11783998 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11783998&query_hl=6 Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo.
Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13625-30. PMID: 11087820 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11087820&query_hl=1 Selected publication list assembled by BioEDEN, Inc, 2008. Existen actualmente unas 484 publicaciones revisadas en www.pubmed.gov
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